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Title: Efficacy Of Beta Oscillations In Identifying Effective Contact Point While Programming In Advanced Parkinson's Disease Patients
e-poster Number: INSIM101
Category: Neurosurgery
Author Name: Manish Baldia
Institute: Jaslok Hospital and Research Centre
Co-Author Name: Paresh K Doshi, Bharati Karkera, Sonali Vasnik, Pettarusp Wadia
Abstract :
Aim and Objectives
To measure local field potential (LFP) while programming with Medtronic Percept PC device in Advanced Parkinson Disease patients and correlate the derived contact point with the effective contact point
Methods
Patients with advanced Parkinson disease implanted with the Medtronic Percept PC DBS device were selected. Age, duration of disease, OFF period rigidity, bradykinesia and LFP’s of different contact points were documented. Contact point with the highest beta range frequency was identified and cross checked with the contact point yielding the best clinical response.
Results
There were 7 patients (14 electrodes) included in the study. Mean duration of their Parkinson’s disease was 10.7 years (7 – 14 years). Beta band LFP’s obtained were in the range of 13.67 to 27.34 hertz. Out of 14 electrodes, three electrodes (21%) did not show Beta band due to artefact (2) and unknown cause (1). Among the 11 electrodes which showed beta band, 10 (90.9%) correlated with the final effective contact point.
Discussion and Conclusion
Adaptive stimulation has gained significance with the technology of measuring the neuronal activity in brain. Local field potential (LFP) are discharges recorded from a group of neurons surrounding the electrode and are the extracellular field generated by the synaptic membrane currents. Beta band LFP recordings are an interesting new concept for assisting in the DBS programming. Our initial experience has shown promising results. However, a greater number of patients are required to know their true potential in detecting the effective contact point.
